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Special Thanks to my team and Nicholas Norwitz – Oxford Ketone PhD Researcher and Harvard Med Student – for working diligently on this research as well!
Key Studies – Rebuttal Proof
(Virta Two-Year Study a.k.a.:) Athinarayanan S. … Phinney S. … Long-Term Effects of a Novel Continuous Remote Care Intervention Including Nutritional Ketosis for the Management of Type 2 Diabetes: A 2-Year Non-randomized Clinical Trial. Frontiers in Endocrinology, 2019.
The ketogenic diet had a 74% two-year adherence rate.
Over the two years, the ketogenic group demonstrated a 54.7% diabetes reversal rate, compared to 10.5% in the usual care group. (Usual care is defined as standard of care treatment overseen by professional endocrinologists and dietitians.)
Over the two years, the ketogenic group demonstrated a decrease in HbA1c from 7.5 to 6.6, whereas the usual care group exhibited an increase from 7.7 to 8.2.
Forsythe C. … Volek J. Comparison of Low Fat and Low Carbohydrate Diets on Circulating Fatty Acid Composition and Markers of Inflammation. Lipids, 2008.
People were split in two diet groups: a low-fat group and a ketogenic group (also known as the Very Low Carb Ketogenic Diet group). The ketogenic group was allowed to eat ad libitum and spontaneously reduced their intake to 1500 Calories/day. The low-fat group was restricted to 1500 Calories/day to match. The ketogenic group steadily lost twice as much weight over 12 weeks as the low-fat group, 10 kilograms (22 pounds) in the ketogenic group as compared to 5 kilograms (11 pounds) in the low-fat group.
More strikingly, despite the fact that the ketogenic group ate three times more saturated fat than the low-fat group, 36 grams per day as compared to 12 grams per day, the levels of saturated fat in the ketogenic group’s blood decreased by more than twice that of the low-fat group. In other words, the ketogenic group ate more fat and this resulted in less fat in their bloodstream.
Minnesota Coronary Study of 1973. Data suppressed in favor of Ancel Keys’ Saturated Fat Heart Hypothesis.
Initiated in 1973, the Minnesota Coronary Study was the most rigorous test of Keys’ hypothesis conducted in the 20th century. It included 9,000 people split into two groups (a low and a high saturated fat group) who were kept in an institution and provided with highly controlled meals. The low saturated fat group received a diet that included 9% saturated fat, which is in line with current USDA dietary guidelines, and the high saturated fat group received a diet that included 18% saturated fat. However, when the study was completed 5 years later, the results weren’t published. 20 years later, when the principal investigator of the study was finally asked why the results, which showed no difference in cardiac events between the groups, had been suppressed, he replied, “We were disappointed in the way the results turned out.”
A re-analysis of the recovered data from the Minnesota Coronary Study, conducted by Ramsden C. et al. in the British Medical Journal in 2016, found, “There was no evidence of benefit in the intervention group for coronary atherosclerosis or myocardial infarcts” and further that, “there was a 22% higher risk of death for each 30 mg/dL reduction in serum cholesterol.”
Multiple lines of evidence show that LDL is not a good predictor of heart disease. Rather, only small dense LDL, which is informed by HDL, TAGs, and HbA1c (all of which improve on a ketogenic diet), appear to matter.
Ketones (βHB) bind G-protein coupled receptors on cell surfaces and bind Histone Deacetylases within cells to change signaling pathways and alter gene expression.
βHB also binds directly to DNA histones to alter the way in which our genetic library is read to reduce people risk for Alzheimer’s diabetes, and cancer, to name just a few examples.
Through the above mechanisms, and more, ketone signaling decreases the four fundamental pathologies underlying all chronic diseases: (1) mitochondrial dysfunction, (2) oxidative stress, (3) inflammation, and (4) cell death.
Nicholas Norwitz – Oxford Ketone PhD Researcher and Harvard Med Student: