When the toxaemia levels surpass the toleration point, symptoms arise.
The human body is one of the most tolerant of all the lifeforms when it comes to handling substances, forces, influences, and conditions that are less than ideal. Few, if any, other creatures can handle such a broad array of hardships as well as humans can. Many creatures are so sensitive that we can use them as indicators to tell us that something is wrong, before we ourselves are even aware that a problem exists. Thus we have the classic scenario of the canary in the coalmine, whereby the canary serves as a sentinel alerting the miners to the fact that dangerous fumes are present in potentially deadly concentrations.
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