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Measure Effect of Keto & Fasting on Fat Loss | Simple Formula

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Measure Effect of Keto & Fasting on Fat Loss | Simple Formula – Thomas DeLauer

The GKI, or the Glucose Ketone Index, is a formula that tracks the ratio of blood glucose to ketones as a single value – it’s a biomarker for tracking your metabolic health as well as your level of ketosis

Use in Studies

Developed by Dr. Thomas Seyfried for management of brain cancer

Was created to track the zone of metabolic management for brain tumor management – a biomarker that refers to the molar ratio of circulating glucose over bHB

Brain tumor cells are dependent on glucose for survival and cannot effectively use ketone bodies as an alternative fuel, a zone of metabolic management can be achieved under conditions of low glucose and elevated ketones

Ketone bodies also prevent neurological symptoms associated with hypoglycemia, such as neuroglycopenia, which allows blood glucose levels to be lowered even further

Hence, ketone body metabolism can protect normal brain cells under conditions that target tumor cells

The zone of metabolic management is considered the therapeutic state that places maximal metabolic stress on tumor cells while protecting the health and vitality of normal cells

Dr. Seyfried noticed in his studies that the therapeutic benefits of keto increased with the lower the glucose ketone index ratio gets – a GKI of lower than 1.0 is prime therapy for patients with cancer

Study #1 – Journal of the American College of Nutrition

The first study evaluated two pediatric patients; one with an anaplastic astrocytoma, and another with a cerebellar astrocytoma – both individuals were placed on a keto diet for 8 weeks

During the 8-week treatment period, GKI dropped from about 27.5 to about 0.7 – 1.1 in the patients

The patient with the anaplastic astrocytoma, who did not have a response to prior chemotherapy, had a 21.7% reduction in fluorodeoxyglucose uptake at the tumor site (no chemotherapy during diet)

The patient with the cerebellar astrocytoma received standard chemotherapy concomitant with the ketogenic diet

Fluorodeoxyglucose uptake at the tumor site in this patient was reduced by 21.8% – quality of life was markedly improved in both children after initiation of the KD

The patient’s GKI decreased from 37.5 to 1.4 in the first three weeks of the diet. No discernible brain tumor tissue was detected with MRI in the patient at the end of eight weeks of the calorie restricted ketogenic diet

It is also important to mention that the patient was free of symptoms while she adhered to the KD – tumor recurrence occurred 10 weeks after suspension of the ketogenic diet

**The glucose ketone index isn’t just for cancer treatment. This value is also of importance for people who have blood sugar issues. The GKI also isn’t just for ketosis.**

On Exercise: It is healthy for blood sugar to rise during exercise because the muscles need the excess fuel to compensate for the increased demand placed upon them. But in most people the body will adjust after exercising and bring the blood sugar levels back to normal

On Fasting: Tracking the glucose ketone index can be a very helpful piece of biofeedback to understand how your metabolism is responding during the fasting period. Over time, you can look back at different fasting periods and use the index as an indicator of your metabolic state during the course of the fasting period

With Food: **Blood glucose and ketone values should be measured 2–3 hours postprandial, twice a day if possible – allows individuals to connect their dietary intake to changes in their GKI**

(Your Glucose Level / 18) / Your Ketones Level = Your Glucose Ketone Index

You divide the glucose number by 18 because glucose readings in the U.S. are measured in mg/dL, and dividing by 18 converts that number to mmol/L to match your ketones reading

References

1) The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. (n.d.). Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4367849/
2) The glucose ketone index calculator: a simple tool to monitor therapeutic efficacy for metabolic management of brain cancer. (n.d.). Retrieved from https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-015-0009-2
3) Effects of a ketogenic diet on tumor metabolism and nutritional status in pediatric oncology patients: two case reports. (2013, September 4). Retrieved from https://www.tandfonline.com/doi/abs/10.1080/07315724.1995.10718495
4) Metabolic management of glioblastoma multiforme using standard therapy together with a restricted ketogenic diet: Case Report. (n.d.). Retrieved from https://nutritionandmetabolism.biomedcentral.com/articles/10.1186/1743-7075-7-33

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